TRT Injection Techniques: IM vs. SubQ Explained

Last Updated On March 29, 2025

When it comes to Testosterone Replacement Therapy (TRT), choosing the right injection technique is crucial for comfort, effectiveness, and safety. Two common methods are Intramuscular (IM) and Subcutaneous (SubQ) injections. Here, we’ll break down the differences, benefits, and injection sites for each method to help you decide which is best for you.

What Are IM and SubQ Injections?

• Intramuscular (IM) Injections: Administered deep into a large muscle, such as the gluteus, deltoid, or thigh. This method allows for faster absorption of testosterone due to the muscle’s rich blood supply.
• Subcutaneous (SubQ) Injections: Administered into the fatty tissue just below the skin, usually in areas like the abdomen or thigh. Testosterone is absorbed more slowly compared to IM injections but with consistent results over time.

Pros and Cons of IM Injections

Pros:

• Faster absorption of testosterone, ideal for those who prefer quicker effects.
• Suitable for larger doses of testosterone.
• Established method with a long history of effectiveness in TRT protocols.

Cons:

• Requires a longer needle (typically 1-1.5 inches, 25-27G).
• Can cause more discomfort or soreness at the injection site.
• Greater risk of hitting blood vessels or nerves if not performed correctly.

Pros and Cons of SubQ Injections

Pros:

• Smaller needles (0.5-0.75 inches, 27-29G) make injections less intimidating and less painful.
• Lower risk of hitting blood vessels or nerves.
• May cause less irritation at the injection site for some users.

Cons:

• Slower absorption might not work for everyone, particularly with larger doses.
• Some users report mild lumps or irritation in the fatty tissue.
• Not officially FDA-approved for testosterone administration, although widely practiced.

How to Choose the Right Method

1. Consider Your Dose Size:
   • IM injections handle larger doses more effectively.
   • SubQ injections are better suited for smaller, more frequent doses.
2. Think About Comfort:
   • If needle size is a concern, SubQ injections may be more comfortable.
   • For those with more muscle mass, IM injections can feel less intimidating.
3. Monitor Your Body’s Response:
   • Some users find one method works better than the other for maintaining steady testosterone levels.
   • Experiment with both techniques and track your results through regular bloodwork.
   • If you find a technique that you’re comfortable with, stick with it.
4. Seek Professional Advice:
   • Discuss with your healthcare provider to determine the safest and most effective method for you.

Injection Sites for IM and SubQ

Intramuscular (IM) Sites:

• Glutes (Buttocks): Popular for its large muscle size and low risk of hitting major nerves.
• Vastus Lateralis (Outer Thigh): Easy to access but may be sore after injections.
• Deltoid (Shoulder): Convenient for smaller doses, but limited in volume capacity.
• Quadriceps (Front Outer Quads): Easier to access, but higher risk of pain and hitting nerves

Subcutaneous (SubQ) Sites:

• Abdomen: The most common site due to accessibility and comfort.
• Thigh: An alternative for those who prefer rotating injection sites.

Pro Tip: Always rotate injection sites to minimize irritation, scar tissue buildup, and discomfort.

Sterile Injection Techniques to Follow

Regardless of the method, maintaining sterility is essential to avoid infection or complications:

• Wash your hands thoroughly before preparing the injection.
• Clean the vial and injection site with an alcohol swab.
• Use a new needle and syringe for each injection.
• Dispose of needles in a proper sharps container.

Quick Tip: Invest in high-quality needles and syringes for smoother injections and less discomfort.

Injection Guides

If you’re new to injections and unsure where to start, don’t worry—I’ve got you covered. Check out my in-depth video guides on every injection site used for TRT, making the process simple and easy to follow

Final Thoughts

Choosing between IM and SubQ injections ultimately comes down to your dose, comfort level, and body’s response. Both methods are effective for TRT, so take the time to experiment and determine what works best for you.