Nebido is a quite a unique little snowflake when it comes to testosterone. In this article you’ll learn how long Nebido takes to kick in initially, as well as in between injections.

Nebido is a form of testosterone called testosterone undecanoate.

It is quite different from most other testosterone as it is released much more slowly into the system and is a much longer lasting ester.

The recommended prescription for each injection interval is 10 – 14 weeks, with the average being around every 12 weeks, or 3 months.

Other testosterones are usually injected at much more frequent intervals. This could include every other day; once, twice or three times per week; or, even once every 2-3 weeks, like with Sustanon in some cases.

So naturally there is a bit more confusion around Nebido and how it works.

I want to thank Lars for his great question, which is the basis for today’s article. This is a common question asked repeatedly.

Let’s dig deeper.

Nebido – The First Injection And Loading Phase

The recommended prescription when starting Nebido is to start with one injection and then to follow up with another injection at six weeks after.

This is called the “loading phase”. The purpose of the loading phase is to make sure your testosterone levels are normalised as quickly as possible.

The loading phase is supposed to be prescribed for EVERY patient.

Taken from Nebido’s product information:

”The first injection interval is shorter so that the sustained active drug levels are reached more rapidly and the shorter interval at the beginning of therapy will make sure that testosterone levels are normalised quickly which will ensure fast alleviation of symptoms and complaints.

This shorter starting interval is advisable for every patient, regardless of whether the patient has already used other testosterone preparations or not. It is advisable that patients switching from shorter-acting testosterone injections (such as Testoviron®, Sustanon®) receive their first injection of Nebido® at the time point when their usual testosterone injection would have been due.”

Shockingly, many doctors do not apply this loading phase, despite it being advised in the product information.

If you are starting Nebido, I highly recommend that you push back against your doctor if they refuse to acknowledge the necessity of the loading phase.

Nebido – When Does It Kick In?

Nebido injections should take effect after one to two weeks.

According to the documentation, “One week after the injection, testosterone serum levels are at their maximum level.”

That means that you should start seeing an improvement in your low testosterone symptoms soon after this.

You won’t really feel anything “kick in”. The effects are not usually that strong that it feels like this big kick. Some people may experience that, but it’s not common, especially with Nebido.

Rather, it is a very smooth, subtle process as the testosterone starts to take effect.

Gradually over time, you may notice that some, if not all, of the negative effects you used to feel, have dissolved and gone away. Or, at least, have diminished significantly.

This is how you know it is working.

Timing Your Follow Up Injections

So, once you’re on Nebido and your levels are stable, when do you feel the next injection kick in?

Ideally, you don’t!

Make sure you don’t feel like this between injections

The goal of your TRT should be to ensure that you never go through any “dips”. A dip is when your testosterone levels drop too low. This is usually due to waiting too long for your next injection.

Ideally, you want to time your injections so that the next one takes effect before the previous one has completely worn off.

That way you never notice any dips and you don’t notice the new injection “kick in”. You just continue feeling good, without any interruption.

The only time you would notice an injection take effect, is if you waited too long for your next injection, and the positive effects of the previous shot had worn off and your low T symptoms returned. You should do your best to avoid this.

If you notice that your low-T symptoms start acting up again before your next injection, then you may need to discuss getting your injections more frequently.

While Nebido recommends an injection interval of 12 weeks, you may need to get them sooner.

For example, when I was on Nebido, my injection frequency was reduced to every 7-10 weeks, because waiting any longer than that caused me to experience horrible dips.

Pay attention to your body and take note of when you start to feel your symptoms return. Work with your doctor to find an injection interval that is ideal for you.


The goal of using Nebido and all TRT is to relieve your symptoms of low testosterone and keep them at bay permanently.

Once your treatment has taken effect, you and your doctor should do everything you can to maintain your testosterone levels, without any noticeable dips or side effects.

Knowledge is power, so if your doctor gives you contradictory information regarding Nebido, just show him the website and product information guidelines (listed below under references).

Nebido can be a great solution for many people when used correctly.

If you have any questions regarding Nebido, feel free to leave them in the comments section below.

Till next time.


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Paolo Broccardo

I help men take control of their testosterone, health and lives. Testosterone Replacement Therapy turned my life around and my goal is to help as many men with low testosterone do the same! Thanks to TRT, I traded anxiety, depression and weakness for courage, motivation, strength, love and masculinity. I'd love to help you do the same.

16 CommentsLeave a comment

  • After your 3rd injection what do u do after that..are u meant to stop nebido how do u come off it. I dont plan to be on nebido forever. I havr been on test e before doing what u might a called a mild test cycle amount comming off that made me feel very bad so i didnt do it again. Now im doing nebido i had my first shot week 1 then seconfld shot week4 then third shot week 9 what is the protocol after this do i stop? Or what

    • What you doing is a mild steroid cycle, and not TRT, therefore I can unfortunately not help you. The only advice I can offer is that you make sure you know exactly what you’re doing before you start messing with your natural hormones. If you screw up your hormones, then you very well may have to be on TRT for life.

  • So after discovering that my test was very low, I got my first shot of nebido today. Pretty painful I might add. Haha.
    I am 42 yo
    My GP is saying 3 to 4 months between injections and nothing about a loading phase. Either he doesn’t know or he is trying to save me some money because it is very expensive here in SA and medical aid does not cover it.
    I am so excited to see the results as I suffer from terrible anxiety that keeps me up most nights as well as a serious drop in libido and energy.
    Advice suggestions please.

  • Congrats! Give it time and see how you feel.

    While a loading phase is recommended in the Nebido documentation, many doctors do not follow this protocol. You’ll have to ask yours why they did not. You have to be proactive and raise these questions yourself, because many times they aren’t even aware themselves.

    If after your first round (6 weeks), you see no improvement, discuss the loading phase / booster shot with him.

    Also, feel free to discuss shorter injection intervals (8-12 weeks) with him if necessary, if you don’t see improvements (after 6 months of treatment . And insist on follow up blood work to ensure that your levels are sufficient.

    Hopefully it works for you, and you see improvements in your symptoms.
    Keep us posted and good luck!

  • I am 80 year old male and have been using Nebido for over a decade with consistently excellent results. I know quickly when I need my injection. Remember the prostate requires high test. Levels for healthy functioning. Also high test. Levels maintain muscle mass, bone mass, secondary sex characteristics, general energy and mood levels AND sex drive. works for me.

  • Hi Paolo, I started TRT toda, Nebido.

    I see you’re an old hand at this and I have a few questions if you don’t mind. My level was very low, what was yours when you started and what exercise / diet regimen are you currently on? Have you dropped weight at all and how is your energy and concentration levels?

    Thanks in advance for your response.

    • Congrats on getting treated.

      When my doctor first started me on treatment, I was on 380ng/dl. So this is not as low as many guys like yourself and others are.

      Exercise: Strength training with hypertrophy 4-5 times per week, depending on the program.

      Diet: Plant-based, making sure I get adequate protein. Minimum alcohol.

      I remain between 8-12% body fat depending on the time of year and program, with visible abs all year round. I don’t get more shredded than this because I lift for longevity, not aesthetics primarily. Plus I don’t plan to compete ever. My weight fluctuates according to my program (slow-cutting/slow-bulking focus), but always within healthy ranges.

      TRT has improved my overall fitness immensely, as well as my mood, focus and concentration. It also improved my anxiety a little bit. However, I go to therapy to deal with the other anxiety that I can’t shake off, and therapy works perfectly for that.

      I hope that helps!

  • I am 52 years old and had my first nebido shot in December 2018. After about 3 weeks I did feel a difference however when it got to around week 7 the effects seem to have dissolved. As my doctor said come back every 8 weeks.

    I had my second shot 2 weeks ago. Now I plan to reduce the window for the next shot. Which I will have done in 6 weeks and then after that 8 weeks.

    • Great – you know your own body, so listen to it like you’ve been doing. If 6-8 weeks is what it takes to keep your symptoms clear, then that’s what it should be, if your doctor agrees (hopefully). My sweet spot was every 7-9 weeks and my doctor was happy to comply.

  • Hi. I use gel (tostran 2%) 6 pumps ED now. Too much hassle and not something I want to continue. Enanthate is not available for me, but nebido is. Is this something worth trying?

    1000mg/ 150mg = 6,6 weeks, but the manufacturer says 10-12 weeks between injections. If I get an blood test in the morning every week from week 4-5 to se if levels is still god, what should they be? With the gel, the values is high 2 hours after, so I measure 24h after (15-20 nmol/L, btw. normal is 12-35 n/mol here in Norway). Is it still the same concept or will for ex. the values be way higher after only 4 weeks since the long half-life? Just trying to understand how to get the values “correct” before estimating my next injection.

    I just do not want to use gel anymore, but since I have heard so much negative on nebido I am a little afraid starting to use it. Btw I want kids in the future but then I will try HCG and clomiphene while on trt. Planning to come of meds with so long half-life is just not good I recon. So bad we do not have enanthate here..

    Thank you very much.

    • Nebido is a lot better than Tostran Gel based on my own experience. Many men have great success with it. Others don’t. You’ll need to gauge for yourself.You need to find the right injection interval that works for you. For me, it was around every 8 weeks, but it will all depend on when you feel the effects wearing off. At that point, you need your next injection a week before that. For example, if you feel the effects wearing off in week 9, get your next injection in week 8. You will need to calibrate based on your own response.

      Don’t focus on the numbers, they are largely irrelevant. Base your decisions on your symptoms and keeping the symptoms away. For some people that might be 15nmol, for others it might be 25nmol. Whatever it takes to improve your symptoms is what you need.

  • Hi paolo i am 29 and i am suffering from low energy and no libido and i went to check my free t level and it is 160 i went to see a doctor and he bot me on nebido 10 days gone by no improvement unluckly we dont have good doctors for trt in ksa what other hormones should I test them. …

    • Give the Nebido time to work. Two weeks at least when you first start. Also, make sure you get a booster shot at 6 weeks. This is necessary for your first two injections and is in the Nebido documentation, you can ask your doctor about it. Other hormones you can test are estrodial and SHBG.

  • Hi there I’m on nebido. Had the booster and then next jab at 12 weeks. BT 8 weeks later and my levels have dropped too low. Did you go through booster again or just shorten the window to next shot?

    • My sweet spot for injections was also at about 8 weeks. And luckily my doctor accommodated me. If you’re levels are low like you say, your doctor shouldn’t be able to argue with the blood test results and should accommodate you changing to an injection interval that prevents you from dropping too low. Best of luck.

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